Xlinked hydrocephalus genes: Their proximity to telomeres and high A+T content compared to Parkinson's disease

Hart M, Conrad J, Barrett E, Legg K Ivey G, Lee PHU, Yung YC, Shim JW. Exp Neurol. 2023 (in press).

Opportunities in posthemorrhagic hydrocephalus research: outcomes of the Hydrocephalus Association Posthemorrhagic Hydrocephalus Workshop.

Koschnitzky JE, Keep RF, Limbrick DD Jr, McAllister JP 2nd, Morris JA, Strahle J, Yung YC. Fluids Barriers CNS. 2018 Mar 27;15(1):11. doi: 10.1186/s12987-018-0096-3.PMID: 29587767 Free PMC article. Review.

Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain.

Lake BB, Chen S, Sos BC, Fan J, Kaeser GE, Yung YC, Duong TE, Gao D, Chun J, Kharchenko PV, Zhang K. Nat Biotechnol. 2018 Jan;36(1):70-80. doi: 10.1038/nbt.4038. Epub 2017 Dec 11. PMID: 29227469 Free PMC article.

A comparative strategy for single-nucleus and single-cell transcriptomes confirms accuracy in predicted cell-type expression from nuclear RNA.

Lake BB, Codeluppi S, Yung YC, Gao D, Chun J, Kharchenko PV, Linnarsson S, Zhang K. Sci Rep. 2017 Jul 20;7(1):6031. doi: 10.1038/s41598-017-04426-w.PMID: 28729663 Free PMC article.

Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain.

Lake BB, Ai R, Kaeser GE, Salathia NS, Yung YC, Liu R, Wildberg A, Gao D, Fung HL, Chen S, Vijayaraghavan R, Wong J, Chen A, Sheng X, Kaper F, Shen R, Ronaghi M, Fan JB, Wang W, Chun J, Zhang K. Science. 2016 Jun 24;352(6293):1586-90. doi: 10.1126/science.aaf1204. PMID: 27339989 Free PMC article.

Characterizing transcriptional heterogeneity through pathway and gene set overdispersion analysis.

Fan J, Salathia N, Liu R, Kaeser GE, Yung YC, Herman JL, Kaper F, Fan JB, Zhang K, Chun J, Kharchenko PV. Nat Methods. 2016 Mar;13(3):241-4. doi: 10.1038/nmeth.3734. Epub 2016 Jan 18.PMID: 26780092 Free PMC article.

Lysophosphatidic acid signalling in development.

Sheng X, Yung YC, Chen A, Chun J. Development. 2015 Apr 15;142(8):1390-5. doi: 10.1242/dev.121723. PMID: 25852197 Free PMC article. Review.

Lysophosphatidic Acid signaling in the nervous system.

Yung YC, Stoddard NC, Mirendil H, Chun J. Neuron. 2015 Feb 18;85(4):669-82. doi: 10.1016/j.neuron.2015.01.009. PMID: 25695267 Free PMC article. Review.

Genomic mosaicism with increased amyloid precursor protein (APP) gene copy number in single neurons from sporadic Alzheimer's disease brains.

Bushman DM, Kaeser GE, Siddoway B, Westra JW, Rivera RR, Rehen SK, Yung YC, Chun J. Elife. 2015 Feb 4;4:e05116. doi: 10.7554/eLife.05116.PMID: 25650802 Free PMC article.

LPA receptor signaling: pharmacology, physiology, and pathophysiology.

Yung YC, Stoddard NC, Chun J. J Lipid Res. 2014 Jul;55(7):1192-214. doi: 10.1194/jlr.R046458. Epub 2014 Mar 18.PMID: 24643338 Free PMC article. Review.

Aneuploid cells are differentially susceptible to caspase-mediated death during embryonic cerebral cortical development.

Peterson SE, Yang AH, Bushman DM, Westra JW, Yung YC, Barral S, Mutoh T, Rehen SK, Chun J. J Neurosci. 2012 Nov 14;32(46):16213-22. doi: 10.1523/JNEUROSCI.3706-12.2012.PMID: 23152605 Free PMC article.

Normal human pluripotent stem cell lines exhibit pervasive mosaic aneuploidy.

Peterson SE, Westra JW, Rehen SK, Young H, Bushman DM, Paczkowski CM, Yung YC, Lynch CL, Tran HT, Nickey KS, Wang YC, Laurent LC, Loring JF, Carpenter MK, Chun J. PLoS One. 2011;6(8):e23018. doi: 10.1371/journal.pone.0023018. Epub 2011 Aug 16.PMID: 21857983 Free PMC article.

Lysophosphatidic acid signaling may initiate fetal hydrocephalus.

Yung YC, Mutoh T, Lin ME, Noguchi K, Rivera RR, Choi JW, Kingsbury MA, Chun J. Sci Transl Med. 2011 Sep 7;3(99):99ra87. doi: 10.1126/scitranslmed.3002095.PMID: 21900594 Free PMC article.

FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation.

Choi JW, Gardell SE, Herr DR, Rivera R, Lee CW, Noguchi K, Teo ST, Yung YC, Lu M, Kennedy G, Chun J. Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):751-6. doi: 10.1073/pnas.1014154108. Epub 2010 Dec 21.PMID: 21177428 Free PMC article.

LPA receptors: subtypes and biological actions.

Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J. Annu Rev Pharmacol Toxicol. 2010;50:157-86. doi: 10.1146/annurev.pharmtox.010909.105753.PMID: 20055701. Review.

Neuronal DNA content variation (DCV) with regional and individual differences in the human brain.

Westra JW, Rivera RR, Bushman DM, Yung YC, Peterson SE, Barral S, Chun J. J Comp Neurol. 2010 Oct 1;518(19):3981-4000. doi: 10.1002/cne.22436.PMID: 20737596 Free PMC article.

Identification of neural programmed cell death through the detection of DNA fragmentation in situ and by PCR.

Yung YC, Kennedy G, Chun J. Curr Protoc Neurosci. 2009 Jul;Chapter 3:Unit 3.8. doi: 10.1002/0471142301.ns0308s48.PMID: 19575470

Aneuploid mosaicism in the developing and adult cerebellar cortex.

Westra JW, Peterson SE, Yung YC, Mutoh T, Barral S, Chun J. J Comp Neurol. 2008 Apr 20;507(6):1944-51. doi: 10.1002/cne.21648.PMID: 18273885

Aneuploidy in the normal and diseased brain.

Kingsbury MA, Yung YC, Peterson SE, Westra JW, Chun J. Cell Mol Life Sci. 2006 Nov;63(22):2626-41. doi: 10.1007/s00018-006-6169-5.PMID: 16952055 Review.

Incorporation of bone marrow-derived Flk-1-expressing CD34+ cells in the endothelium of tumor vessels in the mouse brain.

Santarelli JG, Udani V, Yung YC, Cheshier S, Wagers A, Brekken RA, Weissman I, Tse V. Neurosurgery. 2006 Aug;59(2):374-82; discussion 374-82. doi: 10.1227/01.NEU.0000222658.66878.CC.PMID: 16883178

Constitutional aneuploidy in the normal human brain.

Rehen SK, Yung YC, McCreight MP, Kaushal D, Yang AH, Almeida BS, Kingsbury MA, Cabral KM, McConnell MJ, Anliker B, Fontanoz M, Chun J. J Neurosci. 2005 Mar 2;25(9):2176-80. doi: 10.1523/JNEUROSCI.4560-04.2005.PMID: 15745943 Free PMC article.

Hematopoietic stem cells give rise to perivascular endothelial-like cells during brain tumor angiogenesis.

Udani VM, Santarelli JG, Yung YC, Wagers AJ, Cheshier SH, Weissman IL, Tse V. Stem Cells Dev. 2005 Oct;14(5):478-86. doi: 10.1089/scd.2005.14.478.PMID: 16305333

Incorporation of naive bone marrow derived cells into the vascular architecture of brain tumor.

Yung YC, Cheshier S, Santarelli JG, Huang Z, Wagers A, Weissman I, Tse V. Microcirculation. 2004 Dec;11(8):699-708. doi: 10.1080/10739680490521005.PMID: 15726837

The temporal-spatial expression of VEGF, angiopoietins-1 and 2, and Tie-2 during tumor angiogenesis and their functional correlation with tumor neovascular architecture.

Tse V, Xu L, Yung YC, Santarelli JG, Juan D, Fabel K, Silverberg G, Harsh G 4th. Neurol Res. 2003 Oct;25(7):729-38. doi: 10.1179/016164103101202084.PMID: 14579791