Scintillon News
Recent advances and challenges of HIV therapeutics
November 17, 2023 08:30 AM
Dr. Amber Khan and Dr. Nandagopal Paneerselvam in Prof. Brian Lawson's lab review challenges and success of broadly neutralizing antibodies (bNAbs) and antiretroviral therapy for HIV treatment.
A novel genetically encoded tool manipulates redox metabolism with sub-cellular precision and can be used to interrogate the role of reductive stress in various pathologies.
November 13, 2023 08:30 AM
Scintillon Institute scientists validated a soluble transhydrogenase from E. coli (EcSTH) as a genetically encoded tool to induce NADH reductive stress in both mammalian cells and mouse liver. Characterization of the reductive stress using this tool revealed unique transcriptional and metabolic signatures. This new technology will be extremely useful for future studies aimed at identifying the root causes of multiple diseases or conditions linked to mitochondrial metabolism or an imbalance of redox cofactor NAD.