RNA-related cellular processes

My team has been studying the molecular biology of RNA-related cellular processes, such as pre-mRNA splicing, RNA interference (RNAi), microRNA (miRNA) in developmental control, and mRNA as a platform for transgene.

Many of our most exciting research projects were derived from what we had learned about RNA. We are performing experiment in order to answer questions such as: can we use mRNA as the genetic codes to select antibodies by an in vitro display or transcriptome sequencing? Can protein factors that are critical in vivo be delivered in the form of modified mRNAs instead of recombinant proteins? Can we use transfected mRNA/miRNA to determine in vitro cellular fate instead of using growth factors and small molecules for better specificity? Can we use only RNA molecules to edit the chromosome of mammalian cells in order to maintain the protocol completely footprint-free, similar to what we have demonstrated for induced pluripotent stem cell (iPSC) production?

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