Cracan Lab
LABORATORY OF REDOX BIOLOGY AND METABOLISM
Principal Investigator: Valentin Cracan
PUBLICATIONS
Google Scholar:
https://scholar.google.com/citations?user=POAyaKsAAAAJ&hl=en&oi=ao
Complete Publication List:
1). Singh C, Jin B, Shrestha N, Markhard AL, Panda A, Calvo SE, Deik A, Pan X, Zuckerman AL, Ben Saad A, Corey KE, Sjoquist J, Osganian S, AminiTabrizi R, Rhee EP, Shah H, Goldberger O, Mullen AC, Cracan V, Clish CB, Mootha VK, Goodman RP. (2023) ChREBP is activated by reductive stress and mediates GCKR-associated metabolic traits. Cell Metab. https://www.sciencedirect.com/science/article/abs/pii/S1550413123004217?via%3Dihub
2). Pan X, Heacock ML, Abdulaziz EN, Violante S, Zuckerman AL, Shrestha N, Yao C, Goodman RP, Cross JR, Cracan V. (2023) A genetically encoded tool to increase cellular NADH/NAD+ ratio in living cells. Nat. Chem. Biol. https://www.nature.com/articles/s41589-023-01460-w
Associated content:
Murphy AC, McReynolds MR (2023) Toying with reductive stress. Nat. Chem. Biol. https://www.nature.com/articles/s41589-023-01461-9
3). Abdulaziz EN, Bell TA, Rashid B, Heacock ML, Begic T, Skinner OS, Yaseen MA, Chao LH, Mootha VK, Pierik AJ, Cracan V. (2022) A natural fusion of flavodiiron, rubredoxin, and rubredoxin oxidoreductase domains is a self-sufficient water-forming oxidase of Trichomonas vaginalis. J. Biol. Chem. PMCID: 35780837; Aug;298(8):102210
4). Parkhitko AA, Ramesh D, Wang L, Leshchiner D, Filine E, Binari R, Olsen AL, Asara JM, Cracan V, Rabinowitz JD, Brockmann A, Perrimon N (2020) Downregulation of the tyrosine degradation pathway extends Drosophila lifespan. Elife. Dec 15;9:e58053.
5). Cracan V, Titov DV, Shen H, Grabarek Z, Mootha VK (2017) A genetically encoded tool for manipulation of NADP+/NADPH in living cells. Nat. Chem. Biol. 13(10):1088-1095. Featured on the cover: Enzyme Engineering-Dive into the NADPH pool.
6). Li Z, Kitanishi K, Twahir UT, Cracan V, Chapman D, Warncke K, Banerjee R (2017) Cofactor editing by the G-protein metallochaperone domain regulates the radical B12 enzyme IcmF. J. Biol. Chem. 292(10):3977-3987. This article was selected as Editors′ Pick.
7). Titov DV*, Cracan V*, Goodman RP, Peng J, Grabarek Z, Mootha VK (2016) Complementation of mitochondrial electron transport chain by manipulation of NAD+/NADH ratio. Science 352(6282):231-5. * – these authors contributed equally to this work.
8). Jost M, Born DA, Cracan V, Banerjee R, Drennan CL. (2015) Structural basis for substrate specificity in adenosylcobalamin-dependent isobutyryl-CoA mutase and related acyl-CoA mutases. J. Biol. Chem. 290(45):26882-98. Selected as a paper of the week and featured in the section on Cofactor Redox Enzymology of the JBC Virtual Issue.
9). Kitanishi K, Cracan V, Banerjee R. (2015) Engineered and native coenzyme B12-dependent isovaleryl-CoA/pivalyl-CoA mutase. J. Biol. Chem. 290(33):20466-76.
10). Dai N, Zhao L, Wrighting D, Krämer D, Majithia A, Wang Y, Cracan V, Borges-Rivera D, Mootha VK, Nahrendorf M, Thorburn DR, Minichiello L, Altshuler D, Avruch J. (2015) IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and other mRNAs encoding mitochondrial proteins. Cell Metab. 21(4):609-21.
11). Jost M, Cracan V, Hubbard PA, Banerjee R, Drennan CL. (2015) Visualization of a radical B12 enzyme with its G-protein chaperone. Proc. Natl. Acad. Sci. U S A. 112(8):2419-24.
12). Hung V, Zou P, Rhee HW, Udeshi ND, Cracan V, Svinkina T, Carr SA, Mootha VK, Ting AY. (2014) Proteomic mapping of the human mitochondrial intermembrane space in live cells via ratiometric APEX tagging. Mol. Cell. 55(2):332-41. Recommended by Faculty of 1000.
13). Gohil VM, Zhu L, Baker CD, Cracan V, Yaseen A, Jain M, Clish CB, Brookes PS, Bakovic M, Mootha VK. (2013) Meclizine inhibits mitochondrial respiration through direct targeting of cytosolic phosphoethanolamine metabolism. J. Biol. Chem. 288(49):35387-95.
14). Cracan V, Banerjee R. (2013) Cobalt and corrinoid transport and biochemistry. Met. Ions Life Sci. 12:333-74 (Book Chapter).
15). Cracan V, Banerjee R. (2012) Novel B12-dependent acyl-CoA mutases and their biotechnological potential. Biochemistry. 51(31):6039-46.
16). Cracan V, Banerjee R. (2012) Novel coenzyme B12-dependent interconversion of isovaleryl-CoA and pivalyl-CoA. J. Biol. Chem. 287(6):3723-32.
17). Cracan V, Padovani D, Banerjee R. (2010) IcmF is a fusion between the radical B12 enzyme isobutyryl-CoA mutase and its G-protein chaperone. J. Biol. Chem. 285(1):655-66.