Chen Lab
Laboratory of Neural Circuits and Behavior
Principal Investigator: Albert Chen
Gaunt, J.R., Zainolabidin, N., Yip, A.K.K., Tan, J.M., Low, A.Y.T., Chen, A.I.* and Ch'ng T.H.* (2023). Cytokine enrichment in deep cerebellar nuclei is contributed by multiple glial populations and linked to reduced amyloid plaque pathology. J Neuroinflammation 20, 269. *corresponding authors pdf
Low, A.Y.T., Goldstein, N., Gaunt, J., Huang, K.P., Zainolabidin, N., Yip, A.K.K., Carty, J., Choi, J., Ho, H.S.T., Lenherr, C., Balter, N., Miller, A., Azim, E., Sessions, O., Ch’ng, T.H., Bruce, A., Martin, L., Halko, M., Brady, R., Holsen, L., Alhadeff, A., Chen, A.I.*, Betley, J.N.* (2021). Reverse-translational identification of a cerebellar satiation network. Nature 600, 269-273. *corresponding authors pdf news and views
Thanawalla, A.R., Chen, A.I.*, Azim, E*. (2020). The cerebellar nuclei and dexterous limb movements. Neuroscience 450, 168-183. *corresponding authors pdf
Kamath, S., Chen, A.I. (2019). Myocyte enhancer factor 2c regulates dendritic complexity and connectivity of cerebellar Purkinje cells. Molecular Neurobiology 56, 4102-19. pdf
Tan, S., Xiao, Y., Chen, A.I., Soon, T.W., Je, H.S. (2018). Postnatal TrkB ablation in corticolimbic interneurons induces social dominance in male mice. Proceedings of the National Academy of Sciences 115, E9909-9915. pdf
Low, A.Y.T., Thanawalla, A.R., Yip, A.K.K., Kim, J., Wong, K.L.L., Tantra, M., Augustine, G.J., Chen, A.I. (2018). Precision of discrete and rhythmic forelimb movements requires a distinct neuronal subpopulation in the interposed anterior nucleus. Cell Reports 22, 2322-33. pdf
Tantra, M., Guo, L., Kim, J., Zainolabidin, N., Augustine, G.J., Eulenburg, V., Chen, A.I. (2018). Conditional deletion of Cadherin-13 perturbs Golgi cells and disrupts cognitive and social behaviors. Genes, Brain and Behavior 15, e12466. pdf
Zainolabidin, N., Kamath, S.P., Thanawalla, A.R., Chen, A.I. (2017). Distinct activities of Tfap2A and Tfap2B in the specification of GABAergic interneurons in the developing cerebellum. Frontiers in Molecular Neuroscience 10, 281. pdf
Chen, A.I.*, Zang, K., Masliah, E., Reichardt, L.F. (2016). Glutamatergic axon-derived BDNF controls GABAergic synaptic differentiation in the cerebellum. Scientific Report 6, 20201. *corresponding author pdf
Chen, A.I., Nguyen, C.N., Copenhagen, D.R., Badurek, S., Minichiello, L., Ranscht, B. Reichardt, L.F. (2011). TrkB controls the assembly and maintenance of GABAergic synapses in the cerebellar cortex. The Journal of Neuroscience. 31, 2769-80. pdf
Chen, A.I., de Nooij, J.N., Jessell, T.M. (2006). Graded activity of transcription factor Runx3 specifies the laminar termination pattern of sensory axons in the developing spinal cord. Neuron 49, 395-408. pdf
Novitch, B.G., Chen, A.I., Jessell, T.M. (2001). Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2. Neuron 31, 1-17. pdf
Chen, A., Tang, Y., Zhuo, Y., Wang, Q., Pahk, A., Field, J. (2001). Ras activation of Pak protein kinases. Methods in Enzymology. Regulators and Effectors of Small GTPases 333, 55-61. pdf
Tang, Y., Zhou, H., Chen, A., Pittman, R.N., Field, J. (2000). The Akt proto-oncogene links Ras to Pak and cell survival. Journal of Biological Chemistry 275, 9106-09. pdf
Tang, Y., Chen, A., Zhuo, Y., Wang, Q., Pahk, A., Field, J. (1999). Pak protein kinases as mediators of Ras signaling and cell transformation. A place for Pak on the Ras MAP: More than just another JNK bond. Gene Therapy and Molecular Biology 4, 411-416. pdf