Publications

Gavin AL, Huang D, Huber C, Martensson A, Tardif V, Skog P, Blane T, Thinnes T, Osborn K, Chong HS, Kargaran F, Kimm P, Zeitjian A, Sielski RL, Briggs M, Schulz SR, Zarpellon A, Cravatt B, Teijaro J, de la Torre JC, O’Keeffe M, Hochrein H, Damme M, Teyton L, Lawson BR, and D Namazee.  2018. PLD3 and PLD4 are single-stranded exonucleases that regulate endosomal nucleic-acid sensing. Nat. Immunol. 19(9):942-953.

Lawson BR, Gonzalez-Quintial R, Eleftheriadis T, Farrar MA, Miller SD, Sauer K, McGavern DB, Kono DH, Baccala R, and AN Theofilopoulos. 2015. Interleukin-7 is required for CD4+ T cell activation and autoimmune-mediated neuroinflammation. Clin.  Immunol. 161(2):260-269. 

Cao Y, Axup JY, Ma JS, Wang RE, Choi S, Tardif V, Lim RK, Pugh HM, Lawson BR, Welzel G, Kazane SA, Sun Y, Tian F, Srinagesh S, Javahishvili T, Schultz PG, and CH Kim.  2015.  Multiformat T cell engaging bispecific antibodies targeting human breast cancers.  Angew Chem Int Ed Engl. 54(24):7022-7. 

Ramadoss NS, Schulman AD, Choi SH, Rodgers DT, Kazane SA, Kim CH, Lawson BR, and TS Young. 2015.  An anti-B cell maturation antigen bispecific antibody for multiple myeloma. J Am Chem Soc. 137(16):5288-91. 

Wang RE, Liu T, Wang Y, Cao Y, Du J, Luo X, Deshmukh V, Kim CH, Lawson BR, Tremblay MS, Young TS, Kazane SA, Wang F, AND PG Schultz. 2015. An immunosuppressive antibody-drug conjugate. J Am Chem Soc. 137(9):3229-32. 

Kularatne SA, Deshmukh V, Ma J, Tardif V, Lim RK, Pugh HM, Sun Y, Manibusan A, Sellers AJ, Barnett RS, Srinagesh S, Forsyth JS, Hassenpflug W, Tian F, Javahishvili T, Felding-Habermann B, Lawson BR, Kazane SA, and PG Schultz. 2014. A CXCR-4 targeted site-specific antibody-drug conjugate. Angew Chem Int Ed Engl. 53(44):11863-7.

Lu H, Zhou Q, Deshmukh V, Phull H, Ma J, Tardif V, Naik RR, Bouvard C, Zhang Y, Choi S, Lawson BR, Zhu S, Kim CH, and PG Schultz. 2014. Targeting human C-type lectin-like molecule with a bispecific antibody for immunotherapy of acute myeloid leukemia. Angew Chem Int Ed Engl. 53(37):9841-5.

Kim CH, Axup JY, Lawson BR, Yun H, Tardif V, Choi SH, Zhou Q, Dubrovska A, Biroc SL, Marsden R, Pinstaff J, Smider V and PG Schultz. 2013. A bispecific small molecule antibody conjugate targeting prostate cancer.  PNAS 110(44):17796-801. 

*Deshmukh VA, Tardif V, Lyssiotis CA, Green CG, Kerman B, Kim HJ, Padmanabhan K, Swoboda J, Ahmad I, Kondo T, Gage FH, Theofilopoulos AN, and BR Lawson‡, PG Schultz‡, LL Lairson ‡. 2013.  A regenerative approach to the treatment of multiple sclerosis. Nature 502(7471):327-32.  (‡ contributed equally as senior author) (with accompanying editorial)

Koh Y-T, Scatizzi, J, Lawson BR, Pollard KM, Baccala R, Theofilopoulos AN, and DH Kono.  2013. Role of Nucleic Acid Sensing Toll-Like Receptors in Diverse AutoAb Specificities and Antinuclear Ab-Producing B Cells. J. Immunol. 190(10):4982-90. 

Tardif V, Manenkova Y, Berger M, Hoebe K, Zou JP, Yuan CS, Kono DH, Theofilopoulos AN, and BR Lawson. 2013.  Critical role of transmethylation in TLR signaling and systemic lupus erythematosus. Clin. Immunol. 147(2):133-43. 

Baccala R, Gonzalez-Quintial R, Schreiber RD, Lawson BR, Kono DH, and AN Theofilopoulos.  2012.  Anti-IFNAR antibody treatment ameliorates disease in lupus-predisposed mice. J. Immunol. 189(12):5976-84. 

Eleftheriadis T, Pissas G, Liakopoulos V, Stefanidis I, Lawson BR. 2012. Toll-like receptors and their role in renal pathogenesis.  Inflamm Allergy Drug Targets 11(6):464-77. 

Lawson BR, Eleftheriadis T, Tardiff V, Gonzlaez-Quintial R, Baccala R, Kono DH, and AN Theofilopoulos. 2012. Transmethylation in immunity and autoimmunity. Clin. Immunol. 143:8. 

Gonzalez-Quintial R, Lawson BR, Scatizzi J, Craft J, Kono DH, Baccala R, and AN Theofilopoulos.  2011.  Systemic autoimmunity and lymphoproliferation are associated with excess IL-7 and inhibited by IL-7Ra blockade.  PLOS One 6:e27528. 

Eleftheriadis T, Liakopoulos V, Lawson BR, Antoniadi G, Stefanidis I, and G Galaktidou. 2011.  Lipopolysaccharide and hypoxia significantly alters interlerkin-8 and macrophage chemoattractant protein-1 production by human fibroblasts but not fibrosis related factors.  Hippokratia 15:238. 

Berger M, Krebs P, Crozat K, Li X, Croker BA, Popkin D, Du X, Lawson BR, Theofilopoulos AN, Xia Y, Kovanath K, Moresco EMY, Satoh T, Takeuchi O, Akira S, and B Beutler.  2010.  A Slfn2 mutation causes lymphoid and myeloid immunodeficiency and ablation of the T cell memory phenotype.  Nat. Immunol. 11(4):335.  5  (with accompanying editorial)

Theofilopoulos AN, Gonzalez-Quintial R, Lawson BR, Koh YT, Stern ME, Kono DH, Beutler B, Baccala R. 2010.  Sensors of the innate immune system: their link to rheumatic diseases.  Nat. Rev. Rheumatol. 6(3):146-156. 

Eleftheriadis T and BR Lawson. 2009.  Toll-like receptors and Kidney Diseases.  Inflamm. Allergy Drug Targets. 8(3):191. 

Baccala R, Gonzalez-Quintial R, Lawson BR, Stern ME, Kono DH, Beutler B, and AN Theofilopoulos.  2009.  Sensors of the innate immune system and their role in autoimmune and autoinflammatory rheumatic diseases.  Nat. Rev. Rheumatol. 5(8):448-456. 

Kono DH, Haraldsson MK, Lawson BR, Pollard KM, Koh Y-T, Du X, Arnold CN, Baccala R, Silverman GJ, Beutler BA and Theofilopoulos AN. 2009. Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus. PNAS 106(29):12061. 

Croker BA, Lawson BR, Rutshmann S, Berger M, Eidenschenk C, Blasius AL, Moresco EM, Sovath S, Cengia L, Shultz LD, Theofilopoulos AN, Pettersson S, and BA Beutler.  2008.  Inflammation and autoimmunity caused by a Shp1 mutation depend on IL-1, MyD88, and a microbial trigger.  PNAS 105(39):15028. 

*Haraldsson MK‡, Louis-Dit-Sully CA‡, Lawson BR‡, Sternick G, Rodriguez M, Santiago-Raber ML, Gascoigne NRJ, Theofilopoulos AN and DH Kono.  2008.  The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation.  Immunity 28(1):40. (‡ contributed equally as first author)   (with accompanying editorial)

Lawson BR, Belkowski SM, Whitesides JF, Davis P, and JW Lawson.  2007.  Immunomodulation of murine collagen-induced arthritis by N,N-Dimethylglycine and a preparation of Perna canaliculus.  BMC Complement Altern. Med. 7:20. 

Lawson BR, Manenkova Y, Ahamed J, Chen X, Zou JP, Baccala R, Theofilopoulos AN and CS Yuan.  2007.  Inhibition of transmethylation downregulates CD4 T cell activation and curtails development of autoimmunity in a model system.  J. Immunol. 178(8): 5366. 

Yang ML, Doyle HA, Gee RJ, Clarke S, Lawson BR, Aswad DW, and MJ Mamula.  2006.  Intracellular protein modification in lupus autoimmunity: one mechanism for altered lymphocyte functions.  J. Immunol. 177(7):4541. 

Fu YF, Zhu YN, Ni J, Zhong XG, Tang W, Re YD, Shi LP, Wan J, Yang Y, Yuan C, Nan FJ, Lawson BR and JP Zuo. 2006.  A reversible S-adenosyl-L-homocysteine hydrolase inhibitor ameliorates experimental autoimmune encephalomyelitis by inhibiting T cell activation. J. Pharmacol. Exp. Ther.  319(2):799. 

Fu YF, Wang JX, Zhao Y, Yang YF, He PL, Zhou R, Tang W, Wang GF, Yang Y, Li XY, Li C, Yuan C, Lawson BR, and JP Zuo. 2006.  S-adenosyl-L-homocysteine hydrolase suppression curtails ovalbumin-induced immune responses.  J. Pharmacol. Exp. Thera. 316(3):1229. 

Wu QL, Fu YF, Zhou WL, Wang JX, Feng YH, Liu J, Xu JY, He PL, Zhou R, Tang W, Wang GF, Zhou Y, Yang YF, Ding J, Li XY, Chen XR, Yuan C, Lawson BR, and JP Zou. 2005.  Inhibition of S-adenosyl-L-homocysteine hydrolase induces immunosuppression.  J. Pharmacol. Exp. Thera. 331(2):705.

*Lawson BR, Baccala R, Song J, Croft M, Kono DH, and AN Theofilopoulos.  2004. Deficiency of the cyclin kinase inhibitor p21(WAF-1/CIP-1) promotes apoptosis of activated/memory T Cells and inhibits spontaneous systemic autoimmunity.  J. Exp. Med. 199(4):547. 

Dummer W, Niethammer AG, Baccala R, Lawson BR, Wagner N, Reisfeld RA, and AN Theofilopoulos.  2002.  T cell homeostatic proliferation elicits effective antitumor autoimmunity.  J. Clin. Invest. 110(2):185.  (with accompanying editorial)

Lawson BR, Kono DH, and AN Theofilopoulos.  2002.  Deletion of p21 (WAF-1/Cip1) does not induce systemic autoimmunity in female BXSB mice.  J. Immunol. 168(11):5928.

Duncan SR, Capetanakis NG, Lawson BR, and AN Theofilopoulos.  2002.  Thymic dendritic cells traffic to thymi of allogeneic recipients and prolong graft survival.  J. Clin. Invest. 109(6):755. 

Prud'homme GJ, Lawson BR, and AN Theofilopoulos.  2001.  Anticytokine gene therapy of autoimmune diseases.  Expert Opin. Biol. Ther. 1(3):359. 

Santiago-Raber ML, ‡Lawson BR‡, Dummer W, Barnhouse M, Koundouris S, Wilson CB, Kono DH, and AN Theofilopoulos.  2001. Role of cyclin kinase inhibitor p21 in systemic autoimmunity.  J. Immunol. 167(7):4067.  (‡ contributed equally as first author)

Feeney AJ, Lawson BR, Kono DH, and AN Theofilopoulos.  2001.  Terminal deoxynucleotidyl transferase deficiency decreases autoimmune disease in MRL-Fas(lpr) mice.  J. Immunol. 167(6):3486. 

Lawson BR, Koundouris SI, Barnhouse M, Dummer W, Baccala R, Kono DH, and AN Theofilopoulos.  2001.  The role of a/b+ T cells and homeostatic T cell proliferation in Y-chromosome-associated murine lupus.  J. Immunol. 167(4):2354. 

Theofilopoulos AN, Koundouris S, Kono DH, and BR Lawson.  2001.  The role of IFN-gamma in systemic lupus erythematosus: a challenge to the Th1/Th2 paradigm in autoimmunity.  Arthritis Res. 3(3):136. 

Prud'homme GJ, Lawson BR, Chang Y, and AN Theofilopoulos.  2001.  Immunotherapeutic gene transfer into muscle.  Trends Immunol. 22(3):149.

*Lawson BR, Prud'homme GJ, Chang Y, Gardner HA, Kuan J, Kono DH, and AN Theofilopoulos.  2000.  Treatment of murine lupus with cDNA encoding IFN-gR/Fc.  J. Clin. Invest. 106(2):207.  (with accompanying editorial)

Theofilopoulos AN and BR Lawson. 1999.  Tumour necrosis factor and other cytokines in murine lupus.  Ann Rheum Dis Suppl 1:I49.

Stadtlander CT, Gangemi JD, Stutzenberger FJ, Lawson JW, Lawson BR, Khanolkar SS, Elliott-Raynor KE, Farris HE Jr, Fulton LK, Hill JE, Huntington FK, Lee CK, and TP Monath.  1998.  Experimentally induced infection with Helicobacter pylori in squirrel monkeys (Saimiri spp.): clinical, microbiological, and histopathologic findings.  Lab. Anim. Sci. 48(3):303.